There is queueing traffic due to vehicle fire on the M180 westbound between J5 A15 / A18 / A180 (Barnetby Top) and J4 A15 / A18 (Scawby). Two lorries were involved in an accident causing one to catch fire. It is affecting traffic between Grimsby and Scunthorpe.
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Emergency services have not yet confirmed how many people have died in the collision, which happened just before 1am.
The roads around Yorkshire's tallest building are expected to remain shut until 10am.
The M1 is shut northbound J42 at Lofthouse, causing congestion on the M1 to J39 A636 (Wakefield / Durkar).