The A180 in Grimsby into town partially blocked due to shed load of fish between Birchin Way/Pyewipe Road/Moody Lane and the A16 Victoria Street North/A180 Cleethorpe Road/Lockhill.
There are reports that seagulls picking at the fish are causing an additional hazard.
Emergency services have not yet confirmed how many people have died in the collision, which happened just before 1am.
The roads around Yorkshire's tallest building are expected to remain shut until 10am.
The M1 is shut northbound J42 at Lofthouse, causing congestion on the M1 to J39 A636 (Wakefield / Durkar).