The A629 Halifax Road northbound is closed which is causing heavy traffic due to an accident. One vehicle was involved between A643 Lindley Moor Road (Ainley Top Roundabout) and Elland Riorges Link / Lowfields Way (Lowfields Business Park Roundabout).
Emergency services have not yet confirmed how many people have died in the collision, which happened just before 1am.
The roads around Yorkshire's tallest building are expected to remain shut until 10am.
The M1 is shut northbound J42 at Lofthouse, causing congestion on the M1 to J39 A636 (Wakefield / Durkar).