The M1 northbound is closed due to an overturned lorry across the central reservation between junctions 46 and 47.
One lane is also closed on the Southbound carriageway. Surrounding routes are also expected to be affected.
Emergency services have not yet confirmed how many people have died in the collision, which happened just before 1am.
The roads around Yorkshire's tallest building are expected to remain shut until 10am.
The M1 is shut northbound J42 at Lofthouse, causing congestion on the M1 to J39 A636 (Wakefield / Durkar).