Ellie Simmonds defends the first of her two Paralympic titles that she won in London, four years ago.
The Walsall swimmer goes in the SM6 200m individual medley.
Six-time Paralympic gold medallist Sascha Kindred competes in the men's event.
Kindred won the SM6 200m individual medley in three straight Paralympic Games from Sydney in 2000 to Beijing in 2008.
In London, the Hereford swimmer won a silver.
Sam Ruddock from Rugby is hoping for a medal in the F35 shot put final. He won a silver medal in the European Championships this year.
Loughborough athletes Jonathan Broom-Edwards and Jordan Howe are in the T44 high jump and T35 200m finals respectively.
Nigel Murray from Leamington Spa is in the Great Britain Boccia team going for a bronze medal.