Discount store giant Poundland has stopped selling kitchen knives in all of its 59 stores in the West Midlands.
It has become the first high street retailer to enforce such a ban and others are now expected to follow suit.
Poundland took all knives off shelves in its London stores earlier this year, but chose the West Midlands as the next region because of soaring knife crime.
It said it aimed to take knives out of all its stores across the UK and Ireland by autumn.
A spokesman said the decision was made "after thoughtful reflection about concerns raised by both communities and colleagues".
Poundland retail director, Austin Cooke, said:
The West Midlands has seen a massive rise in the number of stabbings.
It now has the fastest growing rate of knife crime outside London.
A recent report by the Home Office found crimes involving a knife or sharp instrument had risen by more than 1,000 a year between September 2014 and September 2017.