Boots has announced plans to cut as many as 300 jobs from its Beeston headquarters.
Support office roles will be affected by the move which comes after bosses told investors last year that its sales had dipped.
A consultation on the job losses is expected to last for 45 days and the move would lead to a 10 per cent drop in support office staff.
Managing director of Boots UK, Seb James, said in a statement: "The events of the last year have changed consumer behaviours forever and we must adapt our business to meet these new needs.
"This means investing in our digital business, serving customers more efficiently and, above all, becoming much swifter and more agile."
In July last year, the company announced it would cut more than 4,000 jobs in a bid to mitigate the impact of coronavirus.
Its parent company, Walgreen Boots Alliance, has shifted its focus on online retail, upon a significant and "encouraging rise" in sales made on the Boots website.
No stores will be affected by the proposals.
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