The A610 Ripley Road is closed in both directions causing heavy traffic due to recovery work and an accident involving three vehicles.
The closure is between the B6013 Chesterfield Road (The Excavator pub) and Bullbridge Hill.
Police and recovery are at the scene.
As temperatures dip below freezing this weekend, Leicester's gritting lorries have been out and about on the roads.
Here's a full list of the roads affected by the wet and windy weather - with up to an inch of rain expected to fall today.
Dozens of roads are closed across the Midlands this morning due to flooding, including a number of main A routes.