Two HGV's have been involved in a collision on the eastbound carriageway (towards Derby) and on the westbound carriageway (towards Stoke) a car and HGV have also collided.
Fire service and paramedics are dealing with the incident involving the two HGVs as the drivers of both vehicles has sustained injuries, one believed to the seriously.
The air ambulance is currently also at the location.
It is likely that the road will remain closed for a consideration time.
As temperatures dip below freezing this weekend, Leicester's gritting lorries have been out and about on the roads.
Here's a full list of the roads affected by the wet and windy weather - with up to an inch of rain expected to fall today.
Dozens of roads are closed across the Midlands this morning due to flooding, including a number of main A routes.