Blue Islands is stopping its London Southend and Liverpool services from Guernsey because of unsustainable market conditions.
The last day of the London Southend route will be 27 January.
The twice-weekly Liverpool service was due to recommence its summer schedule in May.
The airline’s established services to Southampton, Jersey, East Midlands and Bristol continue as normal.
Any passengers booked on London Southend or Liverpool services will be contacted and offered either an alternative flight or a refund.
London Southend passengers travelling on or after 1 April will be contacted in due course.