The first Aurigny service to Birmingham will leave Guernsey this later this morning.
The airline has introduced the route following Flybe's collapse which came after months of uncertainty over the future of the regional airline.
Flybe was the provider of important air links between the islands and Birmingham, Southampton, Manchester and several other UK transport hubs.
Aurigny bosses hope it will reduce islanders' travel concerns.
Currently a direct return service will run in the late morning to and from Birmingham every day other than Tuesday and Thursday.
The new Exeter flight starts tomorrow with a daily direct return service excluding Tuesday, Wednesday and Saturday.