MPs are calling on the chief executive of Tameside Hospital to quit for presiding over a "prevailing culture of failure".
Three Manchester MPs say they have "no confidence" in Christine Green, the chief executive of Tameside Hospital NHS Foundation Trust, following revelations about patient care.
The standard of care delivered at the trust, in particular the poor performance of A&E and the impact that "poor management" is having on the delivery of health services at the hospital, is the key concern for the MPs.
But the hospital says it commissioned the reviews so it could "understand" more about its delivery and that an action plan is already in place to address the concerns.
Jonathan Reynolds, Andrew Gwynne and David Heyes, the three MPs whose constituents use Tameside as their main local hospital, have issued a joint statement urging Ms Green to go.
The MPs refer to two reviews of the hospital which detail operational deficiencies in how it delivers health services.
Sir Bruce Keogh's findings into standards of treatment at 14 hospitals, which according to The Guardian newspaper are expected to be highly critical, are also due to be published this month.
In their letter to the Keogh review the MPs said: "We feel that the only way the prevailing culture of failure at the hospital can be changed is for the trust to explore reviewing its senior management team.
"We do accept that the chair has only been in post for less than two years and we have confidence that he would be able to help carry forward these changes and provide a level of continuity, however we have no confidence that the chief executive would be able to lead this change.
"Only by taking this specific action, do we believe that both the staff and the wider public will have their confidence restored in the hospital."
In a joint statement issued today the MPs said: "We have campaigned for many years to ensure Tameside Hospital delivers the level of care expected of an NHS hospital. These reports reflect our own concerns and the submission made by us to the Keogh review.
"Although the majority of care delivered by the hospital's frontline staff is praised by patients, we have had serious concerns about aspects of care and governance at the hospital for some time now, which the hospital trust are well aware of. We have always stood by our previous statement that new leadership is required.
"It is for these reasons that we all welcomed the review into the delivery of health services at the hospital trust by Sir Bruce Keogh. We believe this process will give us the chance to address the problems Tameside faces.
"There needs to be significant and sustained improvement across several different areas of care and management. We are confident this can be done, and in doing so local confidence in the hospital's ability to meet the needs of our community can be restored."
Health Secretary Jeremy Hunt said: "Substandard care in hospitals is completely unacceptable - patients should not face excessive waits for treatment and junior doctors must have the support they need from consultants to provide patients with that treatment.
"That is why we are making changes to the CQC's (Care Quality Commission) role, including the appointment of a new chief inspector of hospitals, to provide a better way to expose bad practice where it exists in the NHS and ensure it is dealt with swiftly and decisively. We have also begun discussions on changes to the consultant contract to ensure that trainee doctors have the support they need in the future.
"Prof Sir Bruce Keogh will be publishing his report on Tameside Hospital shortly - this will ensure that they have the support that they need to improve care for their patients."
According to The Guardian the MPs' intervention comes as the CQC, which regulates NHS care, admitted its inspectors found problems at Tameside's A&E unit, which was heavily criticised and depicted as an overcrowded scene of chaos in the two reports.
A CQC spokesman told The Guardian it had instigated an inspection after Jackie Hayden, the postgraduate dean for Greater Manchester, passed on concerns first raised privately with her by a group of junior doctors working in several departments at Tameside.
A spokesman for Tameside Hospital said: "The trust takes the views and concerns of its staff very seriously, including those who work day-in, day out under enormous pressure on the front line. That's why we specifically commissioned the reviews concerned, precisely so we could understand more about our delivery on the front line and how its quality can be maximised alongside support for our staff.
"As soon as the reports were received, we sought to substantiate any comments or observations contained in them, although some comments by individuals were not able to be substantiated.
"Within four weeks, we developed a specific action plan to address the concerns in the reviews. This was signed off by the board over a month ago, a copy sent to (health care regulator) Monitor and has been publicly available via our website since the beginning of June.
"We have a very close and good working relationship with our professional colleagues at the Greater Manchester Deanery and obviously work with them continually to address any concerns raised.
"There were some specific issues raised by the deanery in February. We have discussed them with them and, as we always do, addressed all issues raised.
"Our director of medical education always emphasises at trust induction the appropriate processes/opportunities available to all junior doctors to report any concerns and we assure them we will always address any concerns raised, as we have in these specific instances.
"We were surprised to hear for the first time via The Guardian of alleged comments made during proceedings of our local CCG (clinical commissioning group), with whom we have an excellent working relationship. We can confirm no such comments have been made to us."
The spokesman said there would be no further comment at this time from the trust's chief executive about the MPs' call for her to step down.