Emergency services were called to Parsonage Road shortly before 2.30am this morning, Friday February 10, to a report of a house fire.
Greater Manchester Fire and Rescue Service extinguished the fire.
A man and a woman sadly died at the scene. Their next-of-kin have been informed but formal identification and post-mortems are yet to take place.
Three girls and one boy aged between 10 and 17 were taken to hospital where they are being treated for their injuries.
A man was also taken to hospital and he remains in a serious condition.
A joint investigation with GMFRS has been launched to establish the cause of the fire.
Detective Inspector Tony Lea of GMP's City of Manchester Team said:
Anyone with information is asked to contact police on 101 quoting incident number 140 10/02/17 or the independent charity Crimestoppers, anonymously, on 0800 555 111.