The Duchess of Sussex will accompany the Queen when she carries out a series of official events in Cheshire.
The engagements will be the first time just the Queen and Meghan have taken part in royal events together
The Royal Party is due to drive across the bridge to Widnes after arriving at Runcorn Station.
Anti-toll protestors are expected to demonstrate later, as the Queen officially opens the Mersey Gateway Crossing.
In Chester, members of a dance project which supports those recovering from addiction will perform for the royal guests.
They're based in the city's new Storyhouse Theatre which will be opened by the Queen and the Duchess.
Alex Clifton is the theatre's director.