The Island was also ranked the 12th best place in the world.
Almost three quarters of respondents said their quality of life had improved since moving to the Island.
92% of people said they felt safer on the Island compared to where they used to live.
The Isle of Man, Jersey and Guernsey were new entries in this year's league table.
Jersey and Guernsey came in at 19th and 25th.
It is clear that the quality of life we enjoy in the Isle of Man makes us an attractive destination for those looking to relocate to live and work, but it is also fantastic to see how competitive we are on a global scale in terms of political and economic stability, our wellbeing and family offering."
The HSBC Expat Survey is the longest running independent global survey of expats.
An 'expat' is someone living somewhere that is different to where they were born.
Criteria includes economic stability, wellbeing and family benefits such as finance, education, healthcare and quality of life to provide insights on how countries compare across the globe.