The West Coast Main Line near Warrington is closed for 16 days from Saturday to allow £27 million pounds worth of engineering work to take place. Between 20 July and 4 August Network Rail will be upgrading track, cabling, overhead lines and signalling on the busy Acton Grange junction, which is used by more than 260 trains every day.
Acton Grange is a key section of the West Coast main line between Crewe and Preston.
While the £27 million Great North Rail Project scheme takes place, many train services will be diverted via alternative routes.
Train operators and Network Rail have agreed a plan to keep passengers moving throughout the work.
The plan may mean passengers have to change onto different trains or buses for sections of their journeys.
Passengers are being urged to check www.nationalrail.co.uk before travelling so they know exactly what to expect.
They are also advised to allow more time for their journeys as services are likely to be busier than usual.
This section of the West Coast main line helps connect Chester and Warrington to Manchester in the east and Wigan, Preston, the Lake District and Scotland to the West Midlands and London.
The vital upgrade this summer will bring the outdated track and equipment up to modern standards and further improve the reliability of the economically important West Coast main line.