The former Labour MP Luciana Berger will relocate to London, leaving her Liverpool constituency, and stand for election in the capital.
Ms Berger says the decision has been made to "best navigate" work and raising her young family. In a statement, she says she is "immensely proud" of Liverpool and "grateful" for the support she has received in the city.
She will remain in her Liverpool Wavertree seat until the next General Election, but then become the Liberal Democrat candidate in Finchley and Golders Green.
"Liverpool has been my home since 2010. I met my husband in Liverpool and our two children were born here. During the challenges I have experienced over the past eighteen months, I have been so grateful for the support I have received from the people of Liverpool. I am immensely proud of the city and representing my constituents remains a huge privilege.