There have been two confirmed cases of COVID-19 in Wigan and two in Liverpool.
It takes the total of cases in the region up to 18 following outbreaks in Bolton, Bury, Wirral, Buxton and Wythenshawe.
30 new cases have been announced across the UK today which means the total number of cases now stands at 115.
In a statement, Professor Kate Ardern, director of public health at Wigan Council said:
Meanwhile, a GP surgery in Bury has closed after a possible case of Coronavirus.
Yesterday, England's chief medical officer, Professor Chris Whitty, warned that a UK epidemic is looking "likely".
He said: "Twenty-nine patients were diagnosed who had recently travelled from recognised countries or from recognised clusters which were under investigation."
"Three additional patients contracted the virus in the UK and it is not yet clear whether they contracted it directly or indirectly from an individual who had recently returned from abroad. This is being investigated and contact tracing has begun."