There is a full closure in place on the M6 Northbound between Junction 21 (Lymm interchange M56) and 21A (Croft Interchange M62).
A lorry has "jack-knifed" in a ten car collision, which has also resulted in 400 litres of diesel being spilt across all lanes of the carriageway according to Highways England
A spokesperson for North West Ambulance Service said that three ambulances are at the scene and that it appears that seven people have "minor injuries".
Police are advising people to avoid the route if possible and Highways England have warned that there will be significant delays for some time.
Police have also said on Twitter that traffic has started to be turned around at Junction 20 and that they are trying to open Lane 4 past the accident.
Cheshire Police have also confirmed that Fire and Rescue Services are also at the scene.
A tweet by @MotorwayCameras shows how the lorry involved in the crash has jackknifed across the three lanes on the motorway.