Manchester United will display a banner declaring '"football is nothing without fans" during the club's first match at Old Trafford since the resumption of the Premier League.
The message, quoting former United manager Sir Matt Busby, will be placed in the Stretford End for Wednesday evening's behind-closed doors clash with Sheffield United.
In addition, the stands will also contain a mosaic featuring more than 40,000 supporters from 193 countries in celebration of the club's diversity.
Executive vice chairman Ed Woodward has sympathised with fans unable to attend matches due to the coronavirus pandemic and predicted "difficult" months ahead.
"While everyone at Manchester United is excited to be getting back to playing football, we regret that our fans cannot be in the stadium, and recognise these are difficult times for many people around the world," Woodward told United Review.
Ole Gunnar Solskjaer's fifth-placed side returned to top-flight action with a 1-1 draw at Tottenham as they chase Champions League qualification.