Hundreds of fans gathered to protest outside of Old Trafford ahead of Manchester United's game against Liverpool.
It comes after the match was postponed at the beginning of May as fans stormed the pitch opposing the club's American owners, the Glazer family - who supported the controversial European Super League.
But, despite attempts to stop the match from going ahead, the re-arranged game kicked off as planned as protesters began to return home.
Huge barriers were installed outside the stadium and a massive policing operation was in place.
Flares were lit as hundreds of fans were corralled into a fenced off area outside of the stadium.
Greater Manchester Police confirmed two people had been arrested as "a small number of people seemingly intent on disrupting the fixture."
The arrests are relating to public order offences.
Sports correspondent David Chisnall spoke to Manchester United supporters who say protests will continue until their voices are heard.
There was also a considerable police presence outside the hotel where the Liverpool team was staying.
Despite attempts to stop a number of Liverpool-theme buses from driving to the United ground by fans who blockaded the road, the game went ahead as planned.
On 2 May, protesters managed to make their way into the grounds and gathered on the pitch where half a dozen Greater Manchester Police officers were injured.
One officer, with 20 years service, suffered a severe injury after being slashed in the face.
The relationship between Manchester United fans and the clubs owners has been rocky for around 16 years. But following the proposed super league, which collapsed soon after, fans are proposing a separation.
Fans are renewing calls for a bigger stake in the club's ownership, with many urging the club to adopt the 50+1 model in which fans own 51% of clubs.