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In sentencing Victorino Chua, Mr Justice Openshaw QC described how Grant Misell was left with brain damage after the nurse poisoned him directly.
The court was told Chua flushed his drip with saline contaminated with insulin himself.
He suffered a terrifying hypoglycaemic attack which caused a severe brain injury.
Chua has watched as he was in agony, moaning in pain but did not help him.
In Grant Misell's victim impact statement, he described how his life had been destroyed. He had been an accountant, negotiating multimillion pound deals and now says he can no longer hold down a job stacking shelves.
The Crown prosecution Service (CPS) has spoken of the complex nature of the case against nurse Victorino Chua who poisoned saline at Stepping Hill Hospital.
Nurse Victorino Chua was convicted of murdering two patients but cleared of a third murder by the jury at Manchester Crown Court, which had been deliberating for 11 days.
He was found guilty of murdering Tracy Arden, 44, and Alfred Derek Weaver, 83.
He was cleared of murdering Arnold Lancaster, 81, who was suffering from cancer, but convicted of attempting to cause him grievous bodily harm with intent by poisoning.
In all Chua was convicted of two murders, 22 counts of attempted grievous bodily harm, one count of grievous bodily harm, seven attempts of administering poison and one count of administering poison.
The investigation into the poisonings and deaths at Stepping Hill Hospital was one of the biggest and most complex launched by Greater Manchester Police (GMP).
Operation Roxburg was a multimillion-pound three-and-a-half-year police investigation, involving 7,700 police actions, 659 witnesses, a 28,100-page prosecution file and 16,000 items of unused evidence material.
Greater Manchester Police (GMP) praised the CPS and thanked Stepping Hill Hospital after Victorino Chua was found guilty of murdering and poisoning patients.
GMP said it was "incredulous to believe someone in that vocation to be capable of such malevolence."
Nurse Victorino Chua has been found guilty by a jury at Manchester Crown Court of murdering and poisoning hospital patients at Stepping Hill Hospital.
Sir Peter Fahy, chief constable of Greater Manchester Police (GMP) has apologised to nurse Rebecca Leighton, who was initially arrested in the investigation, while Victorino Chua, who has been found guilty today, kept his silence.
A nurse has been found guilty of two counts of murder by poisoning, and cleared of a third.
49-year-old Victorino Chua was convicted at Manchester Crown Court after 11 days of jury deliberation.
Chua was found to have injected insulin into saline bags and ampoules while working on two wards at Stepping Hill Hospital in June and July 2011.
These were then unwittingly used by other nurses on the ward - leading to a series of insulin overdoses to mainly elderly victims.
After police were called in, Chua was said to have "changed tack" by sabotaging prescription charts, doubling and trebling dosages - some with potentially lethal consequences - leading to his arrest in January 2012.
The Crown said the Filipino father-of-two had decided to take out his personal frustrations on patients "for reasons truly known only to himself".
Among the evidence produced by the prosecution was a self-penned letter found at Chua's home in Stockport after his arrest.
In the letter, described as "the bitter nurse confession" by Chua, the he said he was "an angel turned into an evil person" and "there's a devil in me", who had things he would "take to the grave".