The Sweet Dreams singer tied the knot with Dr Mitch Besser on Saturday in London in what her spokeswoman described as "a private ceremony with friends and family present".
It was reported the ceremony took place on a boat on the River Thames with guests including Oscar winner Colin Firth and comic Ruby Wax.
The Aberdeen-born star posted a photograph of her wedding flowers to her Facebook page for fans to see.
Lennox was announced as an OBE in the 2010 New Year's Honours list for her work in fighting Aids and poverty in Africa.
She has sold more than 80 million albums worldwide with the Eurythmics and as a solo star, winning a string of awards including Grammys, Brits, Ivor Novellos and an Oscar.
Her first marriage to German Hare Krishna devotee Radha Ramen was shortlived and she married Israeli film and record producer Uri Frutmann.
They had two daughters before they divorced in 2000.