Detectives investigating the murder of Syed Jamanoor Islam in Mile End have made three arrests.
The three teenagers aged 18, 15 and 17, were arrested in the early hours of April 16 in South Yorkshire on suspicion of murder.
They are in custody at a south London police station.
An investigation was launched after police were called just after 4.45pm on April 11 to Wager Street, in Mile End to reports of a stabbing.
Officers and the London Ambulance Service attended and found 20-year-old Syed suffering from stab wounds.
He was taken to an east London hospital where he was pronounced dead just after 5.30pm.
Next of kin have been informed and formal identification has taken place
A special post-mortem examination took place on April 13 at Poplar Mortuary and gave the cause of death as a stab wound.
Information to the incident room on 020 8721 4868 , via @MetC or anonymously contact Crimestoppers on 0800 555 111 or via the crimestoppers-uk.org web site.
At this early stage it is believed the victim was with friends in Wager Street when he was approached by a group of males. An altercation began and Syed was stabbed.
An 18-year-old man was arrested on suspicion of murder on April 12 and taken into custody at an east London police station.
He has been bailed pending further enquiries to a date in April.
The Met's Homicide and Major Crime Command are investigating.Police say they are keeping an open mind about a possible motive.