Cesc Fabregas is out of Chelsea's Premier League clash with his former club Arsenal on Saturday.
Fabregas' minor knee injury could present a chance for Mateo Kovacic, on loan from Real Madrid, to make his debut.
Belgium ace Eden Hazard could make his first start since the World Cup.
Arsenal will be without Ainsley Maitland-Niles for their London derby at Chelsea.
The England Under-21 international suffered a small fracture to his leg in last weekend's defeat to Manchester City and faces up to two months out.
Maitland-Niles played at left-back in that loss and is likely to be replaced by fit-again Nacho Monreal, with Danny Welbeck also back in training but Sead Kolasinac (knee), Laurent Koscienly (Achilles) and Carl Jenkinson (ankle) are absent.
Chelsea: Kepa, Caballero, Rudiger, Alonso, Jorginho, Drinkwater, Kante, Barkley, Hazard, Pedro, Moses, Kovacic, Giroud, Zappacosta, Willian, Cahill, Christensen, Azpilicueta, Morata, Luiz, Emerson Palmieri, Ampadu, Loftus-Cheek, Hudson-Odoi.
Arsenal: Cech, Leno, Bellerin, Lichtsteiner, Holding, Mustafi, Mavropanos, Papastathopoulos, Monreal, Nelson, Xhaka, Elneny, Torreira, Guendouzi, Ramsey, Iwobi, Mkhitaryan, Ozil, Welbeck, Lacazette, Aubameyang.