After four separate miscarriages Rebecca and Will Handley became parents to Esme. Little did they know they'd soon be trying to find £500,000 to save her.
It was on holiday in Greece that Rebecca noticed Esme was covered in bruises. Their lives changed immediately.
Esme did fly and went straight to hospital. The cancer - AML - is so aggressive - she began chemo within a week. At first a stem cell transplant looked like a total success.
But the health service doesn't pay for a second round if the cancer returns within a year - which it did with her.
Esme's parents say each case should be treated individually are are now trying to raise half a million pounds to go private.
Will ran six marathons after his mum died suddenly of cancer. But now they are the ones in need. Rebecca and Will say they have been inspired by Esme who plays and smiles like there's nothing wrong, but there's no option to give up.