Forward Son Heung-min is expected to be out for "a number of weeks" after fracturing his right arm in the win at Aston Villa, Tottenham have announced.
The South Korea international will now require surgery on the injury, meaning it is unknown how long he will be absent from the team.
Son suffered the injury in a first-minute challenge with Villa's Ezri Konsa and though he completed the 90 minutes and scored twice.
The news is a further blow to Jose Mourinho who is already missing captain Harry Kane due to a hamstring problem.
A statement on the club's website read: "Son Heung-min is to undergo surgery this week after sustaining a fracture to his right arm.
"The South Korea international suffered the injury during our win against Aston Villa on Sunday.
"Following surgery, our medical staff shall be reviewing management options for Son's rehabilitation with the player expected to be sidelined for a number of weeks."