The Premier League will hold an emergency meeting on Friday, with the Arsenal and Chelsea first-team squads in self-isolation after positive coronavirus tests for Gunners manager Mikel Arteta and Chelsea winger Callum Hudson-Odoi.
This weekend's programme is now in jeopardy after Arsenal confirmed Arteta had contracted Covid-19 before Chelsea reported Hudson-Odoi's case hours later.
The Gunners' trip to Brighton on Saturday was immediately postponed and further games appear certain to follow.
The Premier League could follow the NBA in suspending its season, with US basketball officials clarifying on Thursday the league will be halted for at least 30 days.
On Thursday prime minister Boris Johnson said the country was now moving into the next stage of its planning to combat the pandemic - the delay phase. However, he said that does not yet include cancelling sports events.
"We are considering banning major public events like sporting fixtures," he said.
"The scientific advice is this has little effect on the spread - but it does place a burden on other public services."