Gemma, 29, who starred in the soap as Kerry Skinner back in 2001, vanished from Bethnal Green, East London.
Last night 100 friends carried out a search and handed out leaflets.
Her brother Danny, 33, said: "We are all going out of our mind with worry. Her phone has been switched off since Thursday afternoon."
Death of actress Gemma McCluskie: second man arrested
The brother of a former EastEnders actress was remanded in custody at the Old Bailey today accused of her murder.
The brother of a former EastEnders actress whose body was found dumped in a canal will appear in court today charged with her murder.