We were called at around 1.20pm to reports of a road traffic collision in Poplar High Street involving a car and a motorcycle.
We sent two responders by car, three ambulance crews, two duty officers and London Air Ambulance to the scene.
We treated six patients at the scene. Five patients were taken to the Royal London Hospital.
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Corey Briscoe-McLeary, 38, was seen by a police helicopter crew mounting the pavement and running red lights.
The New West End Company representing businesses in Oxford St, Regent St and Bond St said reopening posed 'extraordinary challenges'.
Dominic Cummings said he drove to Barnard Castle with his wife and child to test his eyesight before making the drive back to London.