The vehicles involved were a Peugeot car, a Scania lorry, a DAF artic, a Mercedes lorry and a Romanian lorry. The man who died was pronounced dead at the scene and his body has now been taken to the mortuary at Princess Alexandra Hospital in Harlow.
He is believed to be a 39-year-old man from Leicester.
Four other people remain in hospital receiving treatment for injuries which are not believed to be serious.
The M25 currently remains shut between junctions 25 and 27 while clean up and repair work continue.
Police have now released the scene to the Highways Agency.
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Work began on the project ten years ago and it should have been ready last year.