A minibus is stuck in a sinkhole along Nine Mile Ride in Crowthorne, after a water main burst underneath the road.
The road is currently closed between St Sebs Roundabout and Pinewood Roundabout.
Police say no one has been injured.
The advice is to seek alternative routes while the road is closed.
The water company, South East Water, have been notified and are working to fix the problem.
The company say customers in the surrounding area may experience no water or low water pressure.