City councillors have declared that central Brighton should be car-free by 2023.
Labour and Green Party councillors have backed a plan which aims to improve air quality and reduce air pollution.
They voted to commission a report, drawn up by October, into how the policy might work.
York and Birmingham made similar commitments earlier this month.
Brighton and Hove City Council has already pledged to make the city carbon neutral by 2030.
A city-wide 'climate assembly' is now being set up to decide what will happen next.
The British Heart Foundation has warned that almost 500 people could die of heart disease caused by pollution in Brighton alone in the next decade.