Eleven patients have died from coronavirus so far at Southampton General Hospital, with more deaths expected.
The University Hospital Southampton NHS Foundation Trust said it is doing everything it can and is urging "everyone to do their bit to support our staff through good hand hygiene and social distancing".
The hospital is currently treating 102 patients who have tested positive for Covid-19.
We would like to thank our teams for their outstanding professionalism and commitment to delivering the best possible care under these difficult circumstances."
Bed capacity at the hospital's intensive care unit has increased from 50 to 150, with plans to expand it up to 200 beds.
The paediatric intensive care unit has moved to the cardiac intensive care unit to free up more critical care space.
The emergency department has been reorganised so patients with minor injuries will be diverted to urgent treatment centres at Lymington and the Royal South Hants Hospital.
Our planning at University Hospital Southampton is advanced. We have done everything possible to be ready and have a clear plan for the weeks ahead."
The Trust is using the private sector to maintain cancer care and other life-threatening operations.
More than 90 outpatient services have also been set-up to run as video clinics.
The Trust said it has "adequate supplies of PPE across the organisation".