Watch Mary Stanley's full report:
Two years after the staff at Salisbury District Hospital faced the fallout from the nerve agent attack, they were dealing with another unknown threat - coronavirus.
Sergei and Yulia Skripal were treated in intensive care at the hospital after being poisoned with Novichok on March 4 2018.
Two years on, the clinical teams faced their second unprecedented challenge in as many years.
Hundreds of patients have been treated for Covid-19 at the hospital, but thankfully the numbers being treated for the disease are levelling off.
Dr Stuart Henderson, who is the Clinical Director for Medicine at the hospital, says it is thanks to the hard work of the public whose impact has been "enormous".
He said: "Had that decision to go into lockdown come a week later or if the public hadn't been so good in complying with the requirements of that we'd be having a very different conversation right now."
Emergency plans were activated and new ways of working had to be found.
The Accident and Emergency department has been divided in two, with a separate entrance for those with symptoms of the virus, and the stroke ward is now dedicated to Covid-19.
Sixteen hospital departments are now offering virtual consultations from maternity, to speech and language therapy.
Despite the major changes, the hospital is still open for all and patients must come if they need help.
NHS staff are still being recruited, retrained and redeployed.