The Campaign for the Protection of Rural England (CPRE) is warning that life in towns and villages up to 25 miles from the rail route will be disrupted by the movement of construction vehicles while the line is being built.
The organisation is publishing its analysis of the impact of the project, in the form of a series of maps, based on information it has obtained from HS2.
According to advance details released to The Mail on Sunday, towns along a 40 mile wide corridor - such as Thame in Oxfordshire, Princes Risborough and Beaconsfield in Buckinghamshire, and Leamington Spa in Warwickshire - will be affected by the millions of extra lorry journeys.
We have considered all construction access routes as part of the development of the draft Environmental Statement on which we consulted earlier this year.
More top news
A coroner delivered his verdict today on the fire at St Michael's Hospice in July 2015.
A man who repeatedly punched a dog in Newbury has been jailed for five months.
A man has been charged with the murder of Kai Archer in Bournemouth.