Paracetamol and Ibuprofen will no longer be free to some patients in Brighton and Hove.
It is part of plans to save the local NHS service half a million pounds.
The proposals will stop the funding of Paracetamol and Ibuprofen prescriptions for short-term minor ailments.
The Brighton and Hove Clinical Commissioning Group says the money could instead fund 16 community nurses, 26 breast cancer treatments, 108 more hip replacements or 400 more treatments for Alzheimer's.
The group is the first in Sussex to introduce this measure and is looking to extend it to other medications later in the year.
Over 100,000 prescriptions for the painkillers were issued last year in Brighton and Hove for conditions such as headaches, sprains, and period pains.
The painkillers are four times more expensive, costing over £45, when prescribed on the NHS compared to under £1 in pharmacies and supermarkets.