Firefighters were called to a blaze at a disused nursing home in Uckfield last night.
East Sussex Fire and Rescue service received 30 calls about the fire at Ridgewood Manor on Lewes Road.
Six fire crews attended the blaze after 8pm last night.
Roads were closed and residents were asked to keep their windows and doors shut.
There were no casualties and an investigation into the cause of the fire is ongoing.