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Manchester United caretaker manager Ole Gunnar Solskjaer has confirmed Alexis Sanchez faces up to six weeks out with a knee injury.
The 30-year-old's Old Trafford career hit its latest roadblock as he was forced off early in the second half of Saturday's 3-2 league win against Southampton.
Chile physio Pedro Onate said Sanchez would be "unavailable to play for between six and eight weeks" - comments Solskjaer was asked about ahead of the second leg of United's Champions League last-16 clash with Paris St Germain.
The Norwegian told a press conference: "It was a bad knee injury so if it's four weeks or six, hopefully he'll recover quickly."
The Chilean joins a lengthy injury list including Anthony Martial, Jesse Lingard, Juan Mata and Ander Herrera.
Nemanja Matic, Matteo Darmian, Phil Jones and Antonio Valencia have also missed recent games and were not among the 20-man squad that travelled to the French capital.
Eight members who have represented the club's academy - Tahith Chong, James Garner, Angel Gomes, Mason Greenwood, Scott McTominay, Andreas Pereira, Marcus Rashford and Brandon Williams - have been included in the group.
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Manchester United manager Jose Mourinho expects Alexis Sanchez to be sidelined for around six weeks because of a hamstring injury he suffered in training.
The Chilean forward was absent from the United squad for their Champions League clash against Young Boys in midweek and is now set for an extended period on the sidelines.
Mourinho said: "(There have been) no scans yet, but the player is experienced, the player knows what the injury is.
"Also from the top of my experience, just the painful scream and the way the injury happened, I know it's going to be for a long time.
"It's not a little muscular injury that in one week or 10 days, the player is ready."
Pressed on the issue further, Mourinho added: "For me, it's January."
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