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The grandfather of six-year-old Veronica Moser-Sullivan, the youngest to die in the massacre, has said it "does not make sense" her killer was spared the death penalty.
Robert Sullivan said: "We have to abide by it, we have to accept it.
"And there are those of us who believe he may be killed in prison which would probably happen sooner than if he were sentenced to death."
The district attorney who prosecuted James Holmes said he should have got the death penalty for his crimes.
Holmes, who killed 12 and wounded 70 when he opened fire in a cinema, will serve life without parole.
George Brauchler told a news conference after the sentencing: "I thought death, I still think death, is justice for what that guy did.
"But the system said otherwise, and I'll honour that and I respect that outcome."
Family members of those who died at the hands of James Holmes have said "justice has not been served" by sparing him the death penalty.
Sandy Phillips, whose 24-year-old daughter Jessica Ghawi was killed in the massacre, said they did not lose loved ones that day.
"They were ripped from us. They were slaughtered in that movie theatre. But the jury chose another way and we have to accept that.
"Our lives are forever altered and the thought that this monster gets to have visitation with his parents... is very hard to accept."
James Holmes will instead serve life in prison with no parole for killing 12 people during a Batman screening in July 2012.Read the full story ›
Relatives and survivors of the massacre at a Colorado cinema three years ago have spoken of their relief that the jury returned a guilty verdict on all charges.
Holmes had pleaded not guilty by reason of insanity to 166 counts of murder, attempted murder, explosives possession and committing a crime of violence.
The trial now enters the punishment phase, where the jury will decide whether Holmes, 27, should be put to death or serve a mandatory life sentence with no possibility of parole.
James Holmes has been found guilty of murder for opening fire inside a Colorado cinema during a Batman film in 2012, killing 12 people.
The jury took two days to reach its verdict.
The 27-year-old gunman pleaded not guilty by reason of insanity. He faces the death penalty.