Leroy Sane is facing a lengthy lay-off after suffering anterior cruciate ligament damage, Manchester City have announced.
The German winger, who limped off in the early stages of Sunday's Community Shield win over Liverpool at Wembley on Sunday, is to undergo surgery in the coming week.
The injury comes after a summer of speculation over the 23-year-old's future, with Bayern Munich having been heavily linked with the player.
Sane has been offered a new contract at the Etihad Stadium but has not yet signed. He has two years left on his present deal.
City have not put a timescale on the player's return but Ilkay Gundogan and Benjamin Mendy have both had seasons ruined by similar problems in recent years.
A statement from the club read: "Leroy will have surgery in the coming week.
"Manchester City will provide Leroy with all the support and guidance he needs, and everyone connected with the Club wishes him a quick and full recovery."
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Proceeds from this summer's Community Shield match at Wembley will be donated to those affected by the Grenfell Tower fire.
The Football Association says it is hoped that the match will raise around £1.25million for the victims of the tragedy and their families. The number of people to have died as a result of the fire, including those classed as missing presumed dead, remains at 79.
The FA will also invite the families of the victims, survivors and emergency service personnel to the game between Arsenal and Chelsea on Sunday, August 6.
FA chairman Greg Clarke said: "Like the rest of the country, we were all deeply saddened by the terrible incident at Grenfell Tower. The suffering and loss for those involved is unimaginable.
"Whilst only a football match, we hope that in some small way through the Community Shield we can help. Two great London clubs will come together to play at the city's most famous stadium just a few miles from Kensington. They will be united in their passion for football, grief at this tragic loss and support for their community.
"Football is for all, and we hope that on August 6 it can in its own way give something back to those who are most in need."
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Arsenal stars have taken to Twitter to share their delight at winning the first silverware of the season.
The Gunners took the Community Shield with a 3-0 victory over Manchester City at Wembley, with four new players among the starting line-up.
Getting soaked in champagne after the game beats getting soaked in rain before the game!! http://t.co/60l05QZ162
Arsenal have won the Community Shield after beating Manchester City 3-0 in the season's curtain-raiser at Wembley Stadium.
First-half goals from Santi Cazorla, Aaron Ramsey put the Gunners in a commanding position at the interval, before Olivier Giroud added a third shortly into the second period.