Fentanyl is a drug that is 100 times more powerful than heroin, and it is Hull's most vulnerable who are at the most at risk from it.
Ross Brennan, 28, conspired with Aarron Gledhill, 30, to import and sell powerful class A drugs to thousands of customers.
The President vows to plough more resources into an addiction epidemic leaving a death toll "equal to September 11 every three weeks".
At a trailer park in Ohio, one man has become the latest casualty in a drug epidemic sweeping the US.
The Home Secretary has pledged to tackle the "terrible blight" of Fentanyl before it causes a deadly crisis like that seen in the US.
AlphaBay, where illegal items including drugs were traded, is one of two dark web markets seized after an US and Europe-led operation.
Speaking to ITV News, a US ambassador warns America's opioids crisis could spread across the Atlantic unless lessons are learnt quickly.
Man-made forms of heroin, are killing addicts in the America, at an almost unimaginable rate.