Native River saw off Might Bite to make all the running in what was an epic duel for the Timico Cheltenham Gold Cup.
Third 12 months ago, the Colin Tizzard-trained Native River (5-1) went two places better to win in the hands of champion jockey Richard Johnson, who was landing the blue riband for the second time after Looks Like Trouble in 2000.
Native River and Might Bite, the 4-1 favourite, were the first two throughout and it was the former who proved stronger from the last fence to prevail by four and a half lengths. The pair were a further four lengths clear of 33-1 chance Anibale Fly in third.
Johnson said: "I'm speechless. He's been a fantastic horse for me and I was lucky to pick up the ride on him.
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Caravaggio maintained his unbeaten record with a superb display in the Commonwealth Cup at Royal Ascot.
The six-furlong contest was billed as one of the races of the week, as the Aidan O'Brien-trained Caravaggio, so impressive in the Coventry Stakes at last year's meeting, took on a couple of major Godolphin-owned contenders in Harry Angel and Blue Point.
Just as he had done when bolting up in last month's Sandy Lane Stakes at Haydock, Clive Cox's Harry Angel was soon racing enthusiastically at the head of affairs and ensured a strong pace.
Blue Point, trained by Charlie Appleby, had beaten Harry Angel in the Pavilion Stakes over the course and distance in early May and loomed up to challenge inside the final furlong.
Harry Angel managed to see him off on this occasion, but had no answer when the more patiently-ridden 5-6 favourite Caravaggio stormed by late on under Ryan Moore and there was three-quarters of a length between them at the line.
Harry Angel was in turn half a length in front of Blue Point, with the trio pulling nicely clear of American challenger Bound For Nowhere.
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Sizing John gave Irish trainer Jessica Harrington her first victory in the Timico Cheltenham Gold Cup with her first runner when coming home a clear-cut winner of jump racing's blue riband prize.
For a full report and race highlights, visit the ITV Racing website
On the opening day of the Cheltenham Festival, Buveur D'Air ran out a brilliant winner of the showpiece Champion Hurdle, powering clear in the hands of jockey Noel Fehily to beat stablemate My Tent Or Yours, who finished second for the third time.
Fehily said of his 5-1 winner: "Early on I felt I was doing too much and I thought it took me a while to get him switched off.
"He's just a very good horse. It's just fantastic. It was a great performance."
To watch highlights of the race, and for more Cheltenham updates, visit the ITV Racing website