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Manchester City manager Pep Guardiola has ruled midfielder Kevin De Bruyne out of Wednesday's Manchester derby at Old Trafford.
The Belgian suffered the latest in a string of injury setbacks this season as he was forced off against Tottenham on Saturday.
"It is a muscular problem," Guardiola said.
"We will see in the next days but tomorrow he is not available."
Guardiola is relishing the prospect of taking on neighbours Manchester United with his side needing a victory to return to the Premier League summit.
"We have to win four games to retain our title," Guardiola added.
"It is not an easy place to go but it is a nice place to go. We know exactly what we have to do.
"It is a derby and all the times we play against United they are special games and players do their best."
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Manchester City manager Pep Guardiola is crossing his fingers that midfielder Kevin De Bruyne's latest injury is not serious.
City's 2-0 victory over Fulham in the Carabao Cup was overshadowed by De Bruyne limping off with an apparent knee problem with five minutes remaining after falling awkwardly in a clash with Timothy Fosu-Mensah.
The Belgium international was making only his second start of the season following knee ligament damage.
And Guardiola hopes De Bruyne will not be sidelined for long heading into a crucial period of the season.
"He's being checked with the doctors so I don't know right now (how he is)," he said.
"I think today Kevin is back, the Kevin we know. He spent a lot of time injured but made a huge effort in Donetsk against Shakhtar and played a few minutes against Spurs in a difficult situation because of the pitch and the physicality.
"Today again he was involved with everything offensively and defensively, so hopefully what happened in the last minutes is not serious."