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Manchester City manager Pep Guardiola has ruled midfielder Kevin De Bruyne out of Wednesday's Manchester derby at Old Trafford.
The Belgian suffered the latest in a string of injury setbacks this season as he was forced off against Tottenham on Saturday.
"It is a muscular problem," Guardiola said.
"We will see in the next days but tomorrow he is not available."
Guardiola is relishing the prospect of taking on neighbours Manchester United with his side needing a victory to return to the Premier League summit.
"We have to win four games to retain our title," Guardiola added.
"It is not an easy place to go but it is a nice place to go. We know exactly what we have to do.
"It is a derby and all the times we play against United they are special games and players do their best."
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Bernardo Silva has welcomed the pressure as title-chasing Manchester City prepare for a critical derby at Manchester United this week.
Wednesday's trip to Old Trafford appears to be the biggest hurdle left facing City as they chase another Premier League crown following Saturday's tense 1-0 win over Tottenham.
Much has been made over whether United fans might actually prefer loathed neighbours City to win the title rather than arch-rivals Liverpool, but Silva does not expect that to affect players' thinking.
United are in a tight battle themselves for a top-four spot and Silva thinks they will be just as hungry for the points.
The Portuguese midfielder said: "We are so happy with the win (on Saturday) and now it's on to another tough one against Manchester United which I think will be crucial for the title.
"It's a big game for us, a big game for them. They need points to be in the top four and we need them to fight for the title.
"So we expect a very difficult game against one of the best sides in England.
"They will be motivated to beat us and we look forward to it. We know we need the win, and the pressure is on - but that's a good thing."
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