Edmonds says he attempted suicide following the "destruction" of his former business Unique Group at the hands of corrupt ex-HBOS bankers.
Deal Or No Deal, one of the simplest game shows on television is to come to an end after nearly 3,000 episodes.
Mr Edmonds was diagnosed with prostate cancer in 2013 and told the ITV programme he overcame his illness by changing his outlook on life.
The presenter was lambasted online after he told a cancer patient that his ill health may have been caused by a "negative attitude".
Noel Edmonds beat off competition from Ant and Dec to be voted Britain's favourite children's TV presenter.
Noel Edmonds puts his healthy looks down to a daily burst of electromagnetic energy, health shakes and slowly exercising in the dark.
Noel Edmonds says the country's economic situation is deterring contestants from taking risks in a bid to win big on Deal or No Deal?
Speaking to the Daily Mirror, he said: "In 2005, when people talked about life-changing money it tended to be, ‘Oh, I would like a sports car, or a holiday in Florida. I would like these things.’
“The reality of the world has changed in a short time and – if you have very little – life-changing money can be £100 or £500.”
Edmonds' comments echo those of quiz show host Chris Tarrant who said the cancellation of 'Who Wants to be a Millionaire?' was down to the public's reaction to the recession.