A woman has died after around 20 vehicles were involved in collisions on the A40.
The woman driver was declared dead at the scene, while another person was taken to the major trauma unit at the nearby John Radcliffe Hospital in Oxford.
A further 10 to 15 casualties were treated at the scene at around 8.25am, a South Central Ambulance Service spokesman said.
The road has been closed in both directions after the multi-vehicle crashes which stretched for more than half a mile near Witney in Oxfordshire, the ambulance service said.
A woman has died after a major crash involving around 20 vehicles on the A40 near Witney in Oxfordshire, Thames Valley Police said.
South Central Ambulance Service spokesman David Gallagher told the Oxford Times: "We’re dealing with two patients, one female and one male, with serious or life-threatening injuries who will be going to the John Radcliffe Hospital Major Trauma Unit.
"We have a further 10 to 15 patients with minor injuries currently being assessed by our staff at the scene.
"The road conditions are reported as being very icy by our staff at the scene."
A Thames Valley Police spokesman said: "Thames Valley Police officers were called today at about 8.25am following reports of a collision involving multiple vehicles on the A40, Witney.
"Officers are at the scene along with the fire and rescue services. A number of people are believed to have been injured.
"Road closures are currently in place, and drivers are advised to avoid the area."
Several people have been injured in four accidents on the A40 in Oxfordshire.
The collisions, involving as many as 20 cars, closed the road between Witney and Burford Road.
An ambulance spokesperson told the Oxford Mail: "We think there at least four collisions. We are trying to work through exactly where people are.
“There are multiple vehicles in multiple accidents and a number of people have been seriously injured."
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