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Tottenham have agreed to sell Mousa Dembele to Chinese Super League side Guangzhou R&F for an undisclosed fee.
The 31-year-old Belgium midfielder, who would have been out of contract in the summer, has signed a three-year deal, according to his new club.
Dembele joined Spurs from Fulham in 2012 and made 250 appearances, but had not played since November 3 due to an ankle injury.
A Spurs statement read: "We have reached agreement with Chinese Super League side Guangzhou R&F for the transfer of Mousa Dembele, subject to international clearance.
"We wish Mousa all the best for the future."
Dembele, who was a part of the Belgium squad that finished third at the World Cup, arrived in England with Fulham in 2010 after joining from Dutch club AZ Alkmaar.
After seven goals in 74 games for the Cottagers, he joined Spurs for £15million.
Dembele struck 10 times for Tottenham, with his last goal coming in a 4-0 win against Bournemouth in 2017, and he played a key role in their rise under boss Mauricio Pochettino.
The midfielder said in an interview shown on Spurs' Twitter account: "I've always had a good experience here. I go away with an unbelievable feeling and with a certain love for the club.
"You always want this, because you have a long period at a club, you have a lot of love for the club but sometimes you separate in a bad way and I don't feel that way.
"Even the reaction I've had from the supporters, everyone is positive with me. They've wished me a lot of luck and happiness. The club is part of my family now."
Spurs defender Jan Vertonghen said: "You have to ask the players who have played against Mousa or with Mousa to get the appreciation he deserves.
"Sometimes it made me angry a bit that people talked about the best midfielders in the Premier League and haven't named Mousa, but I feel like he got that appreciation over the last two years."
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Tottenham have announced they will stay at Wembley until at least the end of February as their wait to move into their new stadium goes on.
Spurs' Premier League home games with Watford, Newcastle and Leicester will all be at the national stadium as the finishing touches are put on their new 62,000-seater home.
The Champions League last-16 home leg with Borussia Dortmund on February 13 will also be at Wembley.
Chairman Daniel Levy has apologised to fans and hopes to provide a further update in the next few weeks.
The club, who have also said a potential FA Cup fifth-round home draw would be at the national stadium, are working with contractors and Haringey Council to determine a schedule for further testing and sign-offs, including the official test events.
They are confident that they will move into their own ground this season, with the home game against Crystal Palace in the middle of March a potential date.
Levy said: "I should like to apologise to our fans and thank you for your continued patience.
"The response from those who attended the familiarisation event was great to hear and reinforced our commitment to deliver an exceptional match-day experience for everyone.
"We shall now seek clarity in respect of building test schedules and test event dates and provide further information on these in the next two to three weeks."
Spurs were originally due to move into their new home for the start of the new season before putting that back to September.
They have an agreement with Wembley to stay there for the rest of the campaign if necessary.
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