Wales prop Wyn Jones has been ruled out of the first Test against Argentina on Saturday and will miss the rest of the summer tour.
Jones suffered a calf injury in training and will return to his Scarlets region for further diagnosis and prognosis.
Fellow Scarlet Rob Evans, who was due to start on the bench on Saturday, comes into the starting XV with Nicky Smith added to the replacements.
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Wales wing George North will join the Ospreys this summer, the Welsh Rugby Union has announced.
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Northampton wing George North has been "disciplined internally" after missing a training session ahead of the March 3 clash with Sale.
Saints boss Alan Gaffney suggested after the Aviva Premiership home defeat to the Sharks that the 25-year-old Wales international, whose contract expires at the end of the season, had not wanted to play for the club.
Northampton said in a statement on Tuesday afternoon: "Following a meeting with the club on Monday, George North accepted responsibility for missing a training session ahead of Saints' Aviva Premiership clash with Sale Sharks earlier this month, and has been disciplined internally.
"North, who returned to training on Monday, will be available for selection for Saints' five remaining matches this season, starting with this weekend's clash against Newcastle Falcons."
Northampton chief executive Mark Darbon said: "George, Alan Gaffney, (attack coach) Alan Dickens and myself had a set of constructive meetings on his return to the club on Monday.
"George accepts the disciplinary action we have taken.
"George has enormous affection for this club and its supporters, and is fully committed to helping the club finish the Aviva Premiership season as strongly as possible.
"We now consider this matter resolved and won't be commenting further."
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