No Metro trains are running between South Gosforth and Four Lane Ends in both directions.
The services are suspended on Saturday 13 and Sunday 14 January, to allow for completion of modernisation work.
A replacement bus service, number 900 will be calling at or close to all stations from South Gosforth to Four Lane Ends.
The bus will turn at Regent Centre.
Metro tickets and passes will be valid on the bus service and the driver will sell tickets.
Nexus, the service provider, are warning the journey will take longer and are advising travellers to allow extra travelling time.